Adolescence, defined as ages 11 through 21, is a time of major physical, cognitive, and psychosocial development. It brings opportunities for improving health and preventing disease and disability, both in the short- and long-term. Our work focuses on improving the quantity and quality of adolescent annual well visits, reducing firearm injury, exploring implementation of school-based health centers, and creating opportunities for meaningful youth engagement. We also support national work to improve the mental health of adolescents and young adults by bringing together state maternal and child health programs and clinical partners to address youth’s needs.