Our faculty, students and fellows are providing paradigm-shifting advances at the cutting edge of science and medicine. We embrace a culture of transdisciplinary partnerships that transcend traditional boundaries in undergraduate, graduate and medical education and pursuit of innovative biomedical research through collaborative team approaches that combine biochemical, molecular, cellular, in vivo genetic, epigenetic, genomic, proteomic and bioinformatic strategies.

 

educationEducation

The goal of the Biochemistry Graduate Program at the University of Vermont is to prepare students for careers in science as both researchers and educators. We expand knowledge of both chemistry and biochemistry while cultivating critical analysis, creativity, and independent study. Learn more >>

Recent News:

Dr. Michael Godsey recently had a new manuscript published - View Here 

Congratulations to Prachi Ghule who won the Akoya Image Contest 

Congratulations to Dr. Stephen Everse who has received the President's Distinguished University Citizenship and Service Award

Congratulations to Dr. Andre van Wijnen who has been selected for the 2024 Mike Horton Award.


microscopeResearch

Each faculty member in UVM’s Department of Biochemistry explores questions using a wide variety of approaches, systems, and techniques. What brings us together is our mutual interest in understanding fundamental biological questions at a molecular level. Learn more >>

 

Congratulations Dr. Jay Silveira has been nominated for the Dean Warshaw Integration Award and Above and Beyond Award 

Congratulations to Dr. Michael Godsey who has been accepted as a member of the Teaching Academy.

Congratulations to Dr. Tom Orfeo who has been awarded Emeritus status in recognition of his significant contributions as a scientist and mentor.


lectureOutreach

With the publication of the Human Genome and other discoveries describing the molecular basis of life, tremendous opportunities await students with the right background and training. Biochemists study the molecular interactions that guide many processes involved in living organisms. Learn more >>

Congratulations to Dr. Stephen Everse who has been nominated for the Dean Warshaw Integration Award, Above and Beyond Award, and Foundations Course Directors Award

Congratulations to Dr. Gary Stein who is the recipient of the 2023 University Distinguished Professor Award

Dr. Michael Godsey joins the graduate faculty in the practitioner-based membership category




 

Spotlight

Education:

Learn more about our Accelerated Master's Program in Biochemistry here.

Research Professional Recruitment:

Postdoctoral Position - Investigating Breast Cancer Compromised Epigenetic Control. How to Apply

Student and Post-Doctoral Spotlight:

Graduate student in the accelerated masters program, John Cullen, is a recipient of the 2024 Jerold and Ingela Lucey Early Career Investigator Prize for Innovations in Infant or Child Health (aka “The Lucey Prize”) for his work on “The Impact of the CALM-AF10 Fusion Protein on Wnt Signaling in Leukemia." (Advisor: Jessica Heath, PhD, Pediatrics.) 

Stein-Lian Lab Post-Doctorate Fellow, Janine Warren, was selected to present her work on "The long noncoding RNA MANCR promotes and stabilizes Triple Negative Breast Cancer" at the 2024 ASCO Annual Meeting taking place May 31st-June 4th 2024 in Chicago. 


Research:

With nearly 1,200 impressions highlights the pre-cancer atlas published in Nature Portfolio: npj Breast Cancer co-authored by a team of six UVM Cancer Center investigators, Janet Stein, Ph.D., Donald Weaver, M.D., Gary Stein, Ph.D., Brian Sprague, Ph.D., Jonathan Gordon, Ph.D., and Mark Evans, Ph.D. Read here.

Atlas paper figure

Featured Publication:

Spatiotemporal higher-order chromatin landscape of human histone gene clusters at histone locus bodies during the cell cycle in breast cancer progression

Ghule PN, Boyd JR, Kabala F, Fritz AJ, Bouffard NA, Gao C, Bright K, Macfarlane J, Seward DJ, Pegoraro G, Misteli T, Lian JB, Frietze S, Stein JL, van Wijnen AJ, Stein GS. Spatiotemporal higher-order chromatin landscape of human histone gene clusters at histone locus bodies during the cell cycle in breast cancer progression. Gene. 2023 Jul 1;872:147441. doi: 10.1016/j.gene.2023.147441. Epub 2023 Apr 23. Erratum in: Gene. 2023 May 11;873:147469. PMID: 37094694; PMCID: PMC10370284.

Spatiotemporal higher-order chromatin landscape of human histone

Two publications report the discovery of long non-coding RNAs that epigenetically mediate human mesenchymal stem cell pluripotency and competency for osteoblast differentiation. 

Gordon JAR, Tye CE, Banerjee B, Ghule PN, van Wijnen AJ, Kabala FS, Page NA, Falcone MM, Stein JL, Stein GS, Lian JB. LINC01638 sustains human mesenchymal stem cell self-renewal and competency for osteogenic cell fate. Sci Rep. 2023 Nov 20;13(1):20314. doi: 10.1038/s41598-023-46202-z. PMID: 37985890; PMCID: PMC10662126.

 

Tye CE, Ghule PN, Gordon JAR, Kabala FS, Page NA, Falcone MM, Tracy KM, van Wijnen AJ, Stein JL, Lian JB, Stein GS. LncMIR181A1HG is a novel chromatin-bound epigenetic suppressor of early stage osteogenic lineage commitment. Sci Rep. 2022 May 11;12(1):7770. doi: 10.1038/s41598-022-11814-4. PMID: 35546168; PMCID: PMC9095685.