Harraz Explains Blood Flow Research Findings to WCAX

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Harraz Explains Blood Flow Research Findings to WCAX

October 16, 2024 by Lucy Gardner Carson

Osama Harraz, Ph.D., assistant professor of pharmacology

(OCTOBER 16, 2024) Osama Harraz, Ph.D., assistant professor of pharmacology, explained to WCAX-TV the significance of his research team’s discovery of the critical role of the protein Piezo1 in neurovascular coupling (the communication between neurons and blood vessels), underscoring the importance of its function for both blood flow regulation and cognitive health.

In short, the work represents a breakthrough that could help in the effort to better understand the causes of dementia and how to stop it.

“Many, many diseases are associated with changes in blood flow in the brain—Alzheimer’s, aging as a risk factor, vascular dementia, small vessel disease of the brain,” Harraz said.

By studying reactions of the brain in mice over three years, the discovery may give researchers a hint of why blood flow deteriorates and causes illness with aging.

The paper by Harraz et al., “Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow,” was recently published in Nature Communications.

Read full story at WCAX-TV