UVM TGIR Logo

Welcome to the Translational Global Infectious Diseases Research Center (TGIR). The TGIR is a Center of Biomedical Research Excellence (COBRE), which support thematic, multidisciplinary centers to augment and strengthen institutional biomedical research capacity. These centers are funded by the National Institutes of Health (NIH). The TGIR is housed within the Department of Microbiology and Molecular Genetics and is closely aligned with the talented team of researchers and clinicians at UVM’s Vaccine Testing Center. 

The TGIR will leverage UVM's substantial existing strengths in global infectious diseases research, complex systems and computational modeling. Bringing investigators from these disparate disciplines together will result in synergies that foster novel, collaborative research.  A team of experienced directors and scientific advisers lead the effort, supported by two new facilities, the “Mathematical and Computational Predictive Modeling” and “Human and Population Research” cores. The TGIR will develop four junior faculty under the mentorship of scientific advisers from three UVM colleges and five departments. 

The TGIR COBRE: bridging the culture gaps between biological and computational biomedical research. 

Projects 

The TGIR currently supports the following junior faculty and their projects:

Dr. Emily Bruce: “Virological and immunological detection of SARS-CoV-2 exposure"

Dr. Jessica Crothers: “Mucosal immunity to polio virus is modified by the gut microbiota, dependent upon cytotoxic cellular responses and can be enhanced via intradermal administration of a mucosally-adjuvanted inactivated polio vaccine (dmLT-IPV)"

Dr. Dev Majumdar: "Evaluation of iDMV-1.0: A Single Dose Self-Amplifying Vaccine"

Dr. Sarah Nowak: “Perception of risk, behavior, and COVID transmission dynamics"

UVM and icddr,b Work to Address Dengue Surge

DiDI Team

Investigators from the International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) in Dhaka, Bangladesh, and the Larner College of Medicine at the University of Vermont (UVM), are the first to study a promising tetravalent dengue vaccine in dengue-endemic Bangladesh. Their work, evaluating the single-dose tetravalent dengue vaccine candidate TV005, demonstrated safety and immune responsiveness in children and adults. The accompanying study was recently published in the journal The Lancet Infectious Diseases.

DiDI TeamThe UVM team, from left: Beth Kirkpatrick, MD; Sean Diehl, PhD; Md. Masud Alam, MBBS;  Marya Carmolli, Dorothy Dickson, MS; Mary-Claire Walsh, PA; Forida Nazib, Dan Bak, MD;  Kristen Pierce, MD

Cores

The TGIR will design, develop and implement three Cores: an Administrative/Academic Core; a Mathematical and Computational Predictive (MCP) Modeling Core; and a Human and Population Research (HPR) Core. The Administrative Core will include the three COBRE directors/Co-PIs, the scientific advisors/senior mentors, the core directors, the internal and external advisory boards, and administrative staff.The MCP Core, led Jason Bates, PhD, will “bridge the culture gap” between biomedical and quantitative data scientists in the analysis and use of big data sets in global infectious diseases, including the spectrum of data from biologic systems to population-based disease transmission and surveillance data. The HPR Core, led by Kristen Pierce, MD, will facilitate and accelerate high-quality clinical and translational human research by the COBRE faculty and will capitalize on the infrastructure of the UVM Vaccine Testing Center.

Team 

The TGIR will develop junior faculty under the mentorship of scientific advisors from three UVM colleges and five departments. Institutional support will enable recruitment of new junior faculty while internal and external advisory committees provide formal, unbiased oversight. Two physician-scientists with complementary strengths in global infectious diseases and an outstanding computational biologist with expertise in disease modeling will lead the TGIR. Learn more about the team.

 

Spotlight

Partners in the Community Education Sessions on the COVID-19 Vaccine gather in Zoom session, including Bidur Dahal, Dr. Avila; Dr. Pierce; Sara Chesbrough, Doma Sherpa, Ms. Vastine;Ms. Merdzanovic; and Ms. Ratsebe.

Kristen Pierce, M.D., infectious disease specialist, Vaccine Testing Center researcher, and TGIR COBRE HPR Core Leader, has been working in collaboration with community leaders to bring vaccine education to New American communities in Vermont. Using virtual education sessions, the group is able to create partnerships, address health disparities, and build trust. To learn more about this effort, click here.